<Reference List> | |
Type: | Preprint |
National /International: | International |
Title: | A second order method for a drug release process defined by a differential Maxwell-Wichert stress-strain relation |
Publication Date: | 2024-11-27 |
Authors: |
- G. C. M. Campos
- José Augusto Ferreira - Gonçalo Pena - Giuseppe Romanazzi |
Abstract: | Polymeric drug delivery platforms offer promising capabilities for controlled drug release thanks to their ability to be custom-designed with specific properties. In this paper, we present a model to simulate the complex interplay between solvent absorption, polymer swelling, drug release and stress development within these types of platforms. A system of nonlinear partial differential equations coupled with an ordinary differential equation is introduced to avoid drawbacks from other models found in the literature. These incorporated a memory effect to account for polymer relaxation but from a numerical point of view, required storing information from all previous time steps, making them computationally expensive. This paper proposes a new numerical method to simulate such drug delivery devices based on nonuniform grids and an implicit midpoint time discretization. Our main results are the proof of second-order convergence of the method for nonsmooth solutions and the scheme's stability under the assumption of quasiuniform grids and a sufficiently small timestep. We also illustrate numerically the second-order convergence result proven in the main result using solutions based on biological information. |
Institution: | DMUC 24-52 |
Online version: | http://www.mat.uc.pt...prints/eng_2024.html |
Download: | Not available |