Centre for Mathematics, University of Coimbra

<Reference List>
Type:	Preprint
National /International:	International
Title:	Drug release from viscoelastic polymeric matrices - a stable and supraconvergent FDM
Publication Date:	2019-06-03
Authors:	- J. S. Borges - José Augusto Ferreira - Giuseppe Romanazzi - E. Abreu
Abstract:	Drug release from viscoelastic polymeric matrices is a complex phenomenon where the main actors are the fluid, the polymeric structure and the drug. As the fluid enters into the polymer, the polymeric chains relax inducing a resistance to the fluid entrance. In contact with the fluid, a dissolution processes takes place and the dissolved drug diffuses through the medium. Our main goal in this paper is to propose a stable finite difference method that leads to a supraconvergent approximations for the fluid, solid and dissolved drug concentrations. The analysis proposed is non-standard in the sense that the error estimates have an important role in the stability analysis.
Institution:	DMUC 19-20
Online version:	http://www.mat.uc.pt...prints/eng_2019.html
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