<Reference List> | |
Type: | Preprint |
National /International: | International |
Title: | Drug release from viscoelastic polymeric matrices - a stable and supraconvergent FDM |
Publication Date: | 2019-06-03 |
Authors: |
- J. S. Borges
- José Augusto Ferreira - Giuseppe Romanazzi - E. Abreu |
Abstract: | Drug release from viscoelastic polymeric matrices is a complex phenomenon where the main actors are the fluid, the polymeric structure and the drug. As the fluid enters into the polymer, the polymeric chains relax inducing a resistance to the fluid entrance. In contact with the fluid, a dissolution processes takes place and the dissolved drug diffuses through the medium. Our main goal in this paper is to propose a stable finite difference method that leads to a supraconvergent approximations for the fluid, solid and dissolved drug concentrations. The analysis proposed is non-standard in the sense that the error estimates have an important role in the stability analysis. |
Institution: | DMUC 19-20 |
Online version: | http://www.mat.uc.pt...prints/eng_2019.html |
Download: | Not available |