Computational modeling of hematopoietic stem/progenitor cells expansion and differentiation
 
 
Description:  Quantifying the effect of exogenous parameters regulating hematopoietic stem/progenitor cells (HSC/HPC) expansion and differentiation will enhance to design robust and efficient protocols to be used for cell‐based therapies. Herein, a computational model was developed that quantitatively describes the effect of microenvironmental parameters on the cell fate decisions during HSC/HPC expansion and differentiation. A set of ordinary differential equations (ODEs) that describe the evolution of cell subpopulations in an in vitro experimental setup was developed. The experimental set up included a two‐stage protocol including HSC/HPC expansion and megakaryocyte lineage commitment [1, 2]. These ODEs were analytically solved and a general solution for each cell subpopulations was fitted to the experimental result, using the least square regression method, to obtain all cell fate rates. The dynamical model developed herein describes cell population behavior in response to the external stimuli during expansion and differentiation stages.
Date:  2016-01-20
Start Time:   14:30
Speaker:  Javad Hatami (Univ. Minho)
Institution:  3B's Research Group Biomaterials, Biodegradables and Biomimetics, University of Minho
Research Groups: -Numerical Analysis and Optimization
See more:   <Main>  
 
© Centre for Mathematics, University of Coimbra, funded by
Science and Technology Foundation
Powered by: rdOnWeb v1.4 | technical support